Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.61 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089895 | 0.90 | AKR1B10 (0.62) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| SCHEMBL7113675 | 0.88 | AKR1B10 (0.65) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| Hydrochloric Acid SCHEMBL10417267 | 0.87 | AKR1B10 (0.63) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| SCHEMBL10415791 | 0.87 | AKR1B10 (0.60) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| SCHEMBL10417266 | 0.87 | AKR1B10 (0.60) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| SCHEMBL10529107 | 0.86 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| SCHEMBL10416214 | 0.85 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| SCHEMBL10417713 | 0.84 | AKR1B10 (0.55) | AKR1B10AKR1A1AKR1B1PLK1CDC25B | |
| Acetic Acid Methyl Ester SCHEMBL9750460 | 0.84 | PLK1 (0.57) | AKR1B10AKR1A1AKR1B1PLK1MAPT | |
| SCHEMBL10385487 | 0.83 | AKR1B10 (0.63) | AKR1B10AKR1A1AKR1B1PLK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281315-B1 | (TRIFLUOROMETHYL) NAPHTHALENE RECOVERY PROCESS | ETHYL CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| EP-0199646-B1 | PROCESS FOR PREPARING 6-ALKOXY-5-TRIFLUOROMETHYL-1-NAPHTOIC ACIDS AND NOVEL 1-CYANO-NAPHTALENE INTERMEDIATES | ETHYL CORPORATION (US) | 1991-09-11 | — | — | EP | disclosed |
| EP-0307519-B1 | Perfluoroalkylation process | ETHYL CORPORATION (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4946987-A | Treatment for complications of diabetes | AYERST, MCKENNA & HARRISON, INC. (CA) | 1990-08-07 | — | — | US | disclosed |
| US-4824989-A | TRIFLUOROMETHYLNAPHTHALENE FROM HALONAPHTHALENE AND TRIFLUOROACETATE | ETHYL CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| US-4824988-A | Process for recovering cuprous iodide catalyst used in synthesis of (trifluoromethyl)napthalenes | ETHYL CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| US-4808748-A | Trifluoromethylation process | ETHYL CORPORATION (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0281315-A2 | (Trifluoromethyl) naphthalene recovery process | ETHYL CORPORATION (US) | 1988-09-07 | — | — | EP | disclosed |
| US-4705882-A | ALDOSE REDUCTASE INHIBITORS, ANTIDIABETIC AGENTS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1987-11-10 | — | — | US | disclosed |
| EP-0199646-A2 | Process for preparing 6-alkoxy-5-trifluoromethyl-1-naphtoic acids and novel 1-cyano-naphtalene intermediates | ETHYL CORPORATION (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4600724-A | ALDOSE REDUCTASE INHIBITOR, DIABETES | AYERST, MCKENNA & HARRISON, INC. (CA) | 1986-07-15 | — | — | US | disclosed |
| US-4590010-A | Substituted naphthoic acid process | ETHYL CORPORATION (US) | 1986-05-20 | — | — | US | disclosed |
| US-4568693-A | ANTIDIATBETIC AGENTS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1986-02-04 | — | — | US | disclosed |
| EP-0059596-B1 | N-NAPHTHOYLGLYCINE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1985-04-24 | — | — | EP | disclosed |
| US-4499310-A | 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its preparation and ethers thereof | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-02-12 | — | — | US | disclosed |
| US-4439617-A | TREATING DIABETES, ENZYME INHIBITOR | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-03-27 | — | — | US | disclosed |
| US-4408077-A | 6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehydes | AYERST, MCKEENA & HARRISON, INC. (CA) | 1983-10-04 | — | — | US | disclosed |