Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424998 | 0.79 | KMT2A (0.43) | CYP2D6LMNAKMT2AMEN1CYP2C19 | |
| SCHEMBL11671946 | 0.76 | SRC (0.43) | CYP2D6LMNAMAPK1KMT2AMEN1 | |
| SCHEMBL4272149 | 0.73 | MEN1 (0.45) | CYP2D6KMT2AMEN1GABBR2GABBR1 | |
| SCHEMBL16153014 | 0.73 | OPRD1 (0.41) | CYP2D6LMNAMAPK1KMT2AMEN1 | |
| SCHEMBL21865391 | 0.73 | ALDH1A1 (0.52) | CYP2D6LMNAKMT2AMEN1KDM4E | |
| SCHEMBL11218815 | 0.71 | LMNA (0.45) | CYP2D6LMNAMAPK1CYP2C19GABBR2 | |
| SCHEMBL10556607 | 0.70 | TDP1 (0.33) | LMNAKDM4ECYP2C19 | |
| SCHEMBL2842918 | 0.70 | CYP2D6 (0.44) | CYP2D6LMNAMAPK1KMT2AMEN1 | |
| SCHEMBL17770614 | 0.69 | HRH1 (0.53) | CYP2D6LMNAKDM4ECYP2C19 | |
| SCHEMBL29069788 | 0.69 | ATM (0.43) | CYP2D6KMT2AMEN1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528172-A1 | (2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists | J. URIACH & CIA. S.A. (ES) | 1993-02-24 | — | — | EP | disclosed |