Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9575317 | 0.98 | NPC1 (0.34) | NPC1KDM4EPRMT5WDR77 | |
| SCHEMBL9575787 | 0.89 | KDM4E (0.32) | NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL9575677 | 0.86 | KDM4E (0.30) | KDM4E | |
| SCHEMBL9197811 | 0.80 | EPHX1 (0.33) | KDM4EMAPTHTTALDH1A1 | |
| SCHEMBL9019792 | 0.78 | EPHX1 (0.31) | KDM4E | |
| SCHEMBL16004199 | 0.72 | NPC1 (0.38) | NPC1KDM4EPRMT5WDR77MAPT | |
| SCHEMBL16004201 | 0.72 | NPC1 (0.38) | NPC1KDM4EPRMT5WDR77MAPT | |
| SCHEMBL9517342 | 0.72 | NPC1 (0.48) | NPC1 | |
| SCHEMBL196700 | 0.72 | NPC1 (0.48) | NPC1 | |
| SCHEMBL13907638 | 0.71 | KDM4E (0.49) | NPC1KDM4EPRMT5WDR77MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225550-A | PROCESS FOR THE PREPARATION OF SUBSTITUTED ACYCLIC NUCLEOSIDES, AND INTERMEDIATES OCCURRING THEREIN | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-06 | — | — | US | disclosed |
| EP-0464511-A2 | Process for the preparation of acyclic, substituted nucleosides and its intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-08 | — | — | EP | disclosed |