Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519397 | 0.90 | TLR2 (0.45) | TLR2ALDH1A1LMNAMEN1HPGD | |
| Hydrochloric Acid SCHEMBL9576024 | 0.85 | TLR2 (0.42) | TLR2ALDH1A1LMNAMEN1HPGD | |
| Hydrochloric Acid SCHEMBL9576028 | 0.85 | TLR2 (0.42) | TLR2ALDH1A1LMNAMEN1HPGD | |
| Hydrochloric Acid SCHEMBL9576034 | 0.85 | TLR2 (0.42) | TLR2ALDH1A1LMNAMEN1HPGD | |
| SCHEMBL31421978 | 0.84 | TLR2 (0.50) | TLR2PLA2G10PLA2G2A | |
| SCHEMBL13058704 | 0.84 | TBXAS1 (0.50) | TLR2ALDH1A1LMNAPLA2G10PLA2G2A | |
| SCHEMBL3757478 | 0.84 | TBXAS1 (0.50) | TLR2ALDH1A1LMNAPLA2G10PLA2G2A | |
| SCHEMBL9576035 | 0.83 | TLR2 (0.49) | TLR2LMNA | |
| SCHEMBL8735923 | 0.83 | CETP (0.48) | TLR2ALDH1A1LMNA | |
| SCHEMBL18641859 | 0.82 | PLA2G10 (0.47) | TLR2PLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0147768-A2 | Glycerin derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-07-10 | — | — | EP | disclosed |