Bicarbonate

Bicarbonate

SCHEMBL9577103

CC(C)(O)C(C)(C)O.O=C(O)O

nearest known ligand 0.57

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Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.57
TSHR P16473 3/20 0.57
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA9 Q16790 1/20 0.46
HMGCR P04035 1/20 0.44
CHRM1 P11229 1/20 0.44
TBXA2R P21731 1/20 0.44
ADRA1A P35348 1/20 0.44
THRB P10828 1/20 0.40
FFAR3 O14843 2/20 0.39
LCK P06239 1/20 0.39
FYN P06241 1/20 0.39
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
HIF1A Q16665 1/20 0.35
LMNA P02545 2/20 0.33
TET2 Q6N021 1/20 0.33
MAPT P10636 1/20 0.32
PTGS1 P23219 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL29127390 0.87 FFAR3 (0.58) ALDH1A1TSHRCA1CA2CA9
Oxalic Acid SCHEMBL27704943 0.87 TSHR (0.53) ALDH1A1TSHRCA1CA2CA9
Bicarbonate SCHEMBL28154408 0.86
Tert-Butanol SCHEMBL1204871 0.86 ALDH1A1 (0.61) ALDH1A1TSHRCA1CA2CA9
Tert-Butanol SCHEMBL6194876 0.86 ALDH1A1 (0.61) ALDH1A1TSHRCA1CA2CA9
Tert-Butanol SCHEMBL8169028 0.86
Tert-Butanol SCHEMBL28305217 0.82 TSHR (0.57) ALDH1A1TSHRCA1CA2CA9
Tert-Butanol SCHEMBL27435481 0.82 ALDH1A1 (0.57) ALDH1A1TSHRCA1CA2CA9
Bicarbonate SCHEMBL9790007 0.80 CA1 (0.56) ALDH1A1TSHRCA1CA2CA9
Bicarbonate SCHEMBL8577664 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0557167-A1 Preparation of fluorinated functional compounds MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-08-25 EP claimed
EP-3717537-B1 REACTION SYSTEM FOR A 1K-POLYURETHANE FOAM COVESTRO DEUTSCHLAND AG (DE) 2023-04-19 EP disclosed
CN-109790276-B Process for preparing elastomers 科思创德国股份有限公司 2022-06-10 CN disclosed
US-11312812-B2 Process for producing elastomers COVESTRO DEUTSCHLAND AG (DE) 2022-04-26 US disclosed
CN-109790275-B Process for preparing multiple bond-containing prepolymers as elastomer precursors 科思创德国股份有限公司 2022-03-15 CN disclosed
US-11091589-B1 Method for producing a polymer which contains double bonds as an elastomer precursor COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2021-08-17 US disclosed
US-20210230361-A1 METHOD FOR PRODUCING A POLYMER WHICH CONTAINS DOUBLE BONDS AS AN ELASTOMER PRECURSOR COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2021-07-29 US disclosed
CN-113166389-A Process for preparing polymers containing double bonds as precursors of elastomers 科思创知识产权两合公司 2021-07-23 CN disclosed
EP-3833706-A1 METHOD FOR PRODUCING A POLYMER WHICH CONTAINS DOUBLE BONDS AS AN ELASTOMER PRECURSOR Covestro Intellectual Property GmbH & Co. KG (DE) 2021-06-16 EP disclosed
US-20210147623-A1 PROCESS FOR THE PREPARATION OF FUNCTIONALIZED POLYOXYALKYLENE POLYOLS COVESTRO DEUTSCHLAND AG (DE) 2021-05-20 US disclosed
US-20160229955-A1 BRANCHED POLYETHER CARBONATE POLYOLS AND PROCESS FOR PREPARATION THEREOF COVESTRO DEUTSCHLAND AG (DE) 2016-08-11 US disclosed
US-20160200866-A1 CROSS-LINKING OF POLYETHER CARBONATE POLYOLS CONTAINING DOUBLE-BONDS, BY ADDING MERCAPTO-COMPOUNDS COVESTRO DEUTSCHLAND AG (DE) 2016-07-14 US disclosed
US-20160200865-A1 RADICAL CROSSLINKING OF POLYETHER CARBONATE POLYOLS THAT HAVE ELECTRON-POOR AND ELECTRON-RICH DOUBLE BONDS COVESTRO DEUTSCHLAND AG (DE) 2016-07-14 US disclosed
US-20160194444-A1 HIGHER FUNCTIONAL POLYETHER CARBONATE POLYOLS OBTAINED USING BRANCHING MOLECULES COVESTRO DEUTSCHLAND AG (DE) 2016-07-07 US disclosed
US-20160185903-A1 LOW VISCOSITY POLYETHER CARBONATE POLYOLS HAVING SIDE CHAINS COVESTRO DEUTSCHLAND AG (DE) 2016-06-30 US disclosed
US-20160130407-A1 POLYETHERCARBONATE-POLYOXYMETHYLENE BLOCK COPOLYMERS COVESTRO DEUTSCHLAND AG (DE) 2016-05-12 US disclosed
US-9273183-B2 Polyether carbonate polyol production method COVESTRO DEUTSCHLAND AG (DE) 2016-03-01 US disclosed
US-20150368396-A1 FUNCTIONALIZED POLYOXYMETHYLENE BLOCK COPOLYMERS COVESTRO DEUTSCHLAND AG (DE) 2015-12-24 US disclosed
US-20150225503-A1 POLYETHER CARBONATE POLYOL PRODUCTION METHOD COVESTRO DEUTSCHLAND AG (DE) 2015-08-13 US disclosed
EP-0557167-A1 Preparation of fluorinated functional compounds MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-08-25 EP disclosed