Tert-Butanol

Tert-Butanol

SCHEMBL1204871

CC(C)(C)O.CC(C)(C)O.O=C(O)O.O=C(O)O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Tert-Butanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.61
TSHR P16473 3/20 0.61
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
HMGCR P04035 1/20 0.47
CHRM1 P11229 1/20 0.47
TBXA2R P21731 1/20 0.47
ADRA1A P35348 1/20 0.47
FFAR3 O14843 2/20 0.42
LCK P06239 1/20 0.42
FYN P06241 1/20 0.42
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
HIF1A Q16665 1/20 0.37
LMNA P02545 2/20 0.35
TET2 Q6N021 1/20 0.35
MAPT P10636 1/20 0.33
PTGS1 P23219 1/20 0.33
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tert-Butanol SCHEMBL8169028 1.00
Tert-Butanol SCHEMBL6194876 1.00 ALDH1A1 (0.61) ALDH1A1TSHRCA1CA2CA9
Tert-Butanol SCHEMBL28305217 0.95 TSHR (0.57) ALDH1A1TSHRCA1CA2CA9
Tert-Butanol SCHEMBL27435481 0.95 ALDH1A1 (0.57) ALDH1A1TSHRCA1CA2CA9
Bicarbonate SCHEMBL28154408 0.90
Tert-Butanol SCHEMBL6273948 0.86
Bicarbonate SCHEMBL9577103 0.86 ALDH1A1 (0.57) ALDH1A1TSHRCA1CA2CA9
Bicarbonate SCHEMBL9790007 0.84 CA1 (0.56) ALDH1A1TSHRCA1CA2CA9
Bicarbonate SCHEMBL8577664 0.84
Tert-Butanol SCHEMBL4348456 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 255 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230331724-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND MEIJI SEIKA PHARMA CO., LTD. (JP) 2023-10-19 US claimed
US-20210371419-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND MEIJI SEIKA PHARMA CO., LTD. (JP) 2021-12-02 US claimed
US-20200048253-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND MEIJI SEIKA PHARMA CO., LTD. (JP) 2020-02-13 US claimed
EP-2857401-B1 NOVEL -LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME MEIJI SEIKA PHARMA CO LTD (JP) 2019-09-18 EP claimed
US-20180258089-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND MEIJI SEIKA PHARMA CO., LTD. (JP) 2018-09-13 US claimed
US-20170233393-A1 BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME MEIJI SEIKA PHARMA CO., LTD. (JP) 2017-08-17 US claimed
US-20160024090-A1 BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME MEIJI SEIKA PHARMA CO., LTD. (JP) 2016-01-28 US claimed
US-20150141401-A1 NOVEL BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME MEIJI SEIKA PHARMA CO., LTD. (JP) 2015-05-21 US claimed
EP-2857401-A1 NOVEL -LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME Meiji Seika Pharma Co., Ltd. (JP) 2015-04-08 EP claimed
US-7902190-B2 Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2011-03-08 US claimed
US-20100075962-A1 INDOL DERIVATIVES, THE METHOD FOR PREPARING THEREOF AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING THE SAME AS AN ACTIVE INGREDIENT KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2010-03-25 US claimed
EP-1068182-B1 PROCESS FOR PREPARING A PROTECTED 4-AMINOMETHYL-PYRROLIDIN-3-ONE LG LIFE SCIENCES LTD (KR) 2005-06-08 EP claimed
US-20040014804-A1 Methods for producing amino-substituted chromanes ELI LILLY AND COMPANY 2004-01-22 US claimed
EP-1286983-A2 METHODS FOR PRODUCING AMINO-SUBSTITUTED CHROMANES Eli Lilly & Company (US) 2003-03-05 EP claimed
WO-2001094331-A2 METHODS FOR PRODUCING AMINO-SUBSTITUTED CHROMANES ELI LILLY & COMPANY (US) 2001-12-13 WO claimed
US-6307059-B1 PREPARATION OF QUINOLONE ANTIBIOTICS. LG CHEMICAL, LTD (KR) 2001-10-23 US claimed
EP-1068182-A1 PROCESS FOR PREPARING A PROTECTED 4-AMINOMETHYL-PYRROLIDIN-3-ONE LG Life Sciences Ltd. (KR) 2001-01-17 EP claimed
WO-1999044991-A1 PROCESS FOR PREPARING A PROTECTED 4-AMINOMETHYL-PYRROLIDIN-3-ONE LG CHEMICAL LTD. (KR) 1999-09-10 WO claimed
US-11998560-B2 Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against multidrug and extensively drug-resistant Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates UNIVERSITY OF MANITOBA (CA) 2024-06-04 US disclosed
EP-0173441-A1 Amino acid derivatives having anti-tumor activity and compositions containing them SANKYO COMPANY LIMITED (JP) 1986-03-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200048253-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND FN1, BMP1, AZI2 ALDH1A1 1362/4885TSHR 1888/4885CA1 3604/4885
US-20100075962-A1 INDOL DERIVATIVES, THE METHOD FOR PREPARING THEREOF AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING THE SAME AS AN ACTIVE INGREDIENT DGAT2, DGAT1, SOAT2 ALDH1A1 908/4885TSHR 2666/4885CA1 4371/4885
US-20040014804-A1 Methods for producing amino-substituted chromanes PFKP, TBXAS1, TBXA2R ALDH1A1 899/4885TSHR 2589/4885CA1 1309/4885
US-20160024090-A1 BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME ME1, MRPL21, FNTB ALDH1A1 502/4885TSHR 1913/4885CA1 1822/4885
US-11998560-B2 Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against multidrug and extensively drug-resistant Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates MGAM, COASY, ABCC1 ALDH1A1 2492/4885TSHR 2797/4885CA1 4252/4885
US-20150141401-A1 NOVEL BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME ME1, FN1, FNTB ALDH1A1 466/4885TSHR 1719/4885CA1 2224/4885
US-20210371419-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND FN1, BMP1, AZI2 ALDH1A1 1362/4885TSHR 1888/4885CA1 3604/4885
US-20180258089-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND FN1, BMP1, AZI2 ALDH1A1 1362/4885TSHR 1888/4885CA1 3604/4885
US-20230331724-A1 PROCESSES FOR PREPARING A DIAZABICYCLOOCTANE COMPOUND FN1, BMP1, AZI2 ALDH1A1 1362/4885TSHR 1888/4885CA1 3604/4885
US-20170233393-A1 BETA-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME FN1, FNTB, CPN1 ALDH1A1 495/4885TSHR 3303/4885CA1 3514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.