Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 5/20 | 0.73 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.73 |
| ▸ | ALB | P02768 | 1/20 | 0.73 |
| ▸ | ESR1 | P03372 | 1/20 | 0.73 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.73 |
| ▸ | RARB | P10826 | 1/20 | 0.73 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | HTR2A | P28223 | 1/20 | 0.73 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.73 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.73 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572744 | 1.00 | CXCR1 (0.73) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Dexibuprofen SCHEMBL30091137 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL19439559 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Dexibuprofen SCHEMBL43531 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL3001 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL19439560 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| (R)-Ibuprophen SCHEMBL29057 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL239446 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL8754799 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL7037276 | 0.85 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58049353-A | — | — | None | — | — | JP | disclosed |
| JP-52118443-A | — | — | None | — | — | JP | disclosed |
| EP-0407588-B1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEM RES (JP) | 1993-12-08 | — | — | EP | disclosed |
| US-5028738-A | Process for producing 2-oxo-3-aromatic carboxylic acid derivatives | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0407588-A1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-01-16 | — | — | EP | disclosed |
| EP-0386243-A1 | PLATINUM (II) COMPLEXES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1990-09-12 | — | — | EP | disclosed |
| JP-S5849353-A | PYRUVIC ACID AMIDE DERIVATIVE | NISSHIN FLOUR MILLING CO LTD | 1983-03-23 | — | — | JP | disclosed |
| JP-S52118443-A | SYNTHESIS OF 3-METHYL-3-(4-ISOBUTYLPHENYL)PYRUVIC ACID | GRELAN PHARMACEUT CO LTD | 1977-10-04 | — | — | JP | disclosed |
| US-3965161-A | Process of producing a 2-(4-alkylphenyl)-propionic acid | NISSHIN FLOUR MILLING CO., LTD. (JA) | 1976-06-22 | — | — | US | disclosed |
| US-3959349-A | 2-Hydroxy-3(4-alkylphenyl)-3-butenoic acid ester and process for the production thereof | NISSHIN FLOUR MILLING CO., LTD. (JA) | 1976-05-25 | — | — | US | disclosed |