Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714097 | 0.90 | CNR2 (0.43) | CA1CA2CA9CA12ABCC9 | |
| SCHEMBL9713906 | 0.89 | L3MBTL1 (0.43) | CA1CA2CA9CA12ABCC9 | |
| SCHEMBL9714074 | 0.84 | CA1 (0.44) | CA1CA2CA9CA12CYP2C19 | |
| SCHEMBL9713843 | 0.83 | MAPT (0.50) | ABCC9ABCC8KCNJ11KCNJ8GAA | |
| SCHEMBL9713975 | 0.81 | HTR6 (0.50) | CA1CA2CA12ABCC9ABCC8 | |
| SCHEMBL10716571 | 0.79 | ATM (0.58) | CA1CA2CA9CA12ABCC9 | |
| SCHEMBL9714060 | 0.78 | CYP2C19 (0.47) | ABCC9ABCC8KCNJ11KCNJ8CYP2C19 | |
| SCHEMBL7195431 | 0.77 | L3MBTL1 (0.63) | CA1CA2CA9CA12CYP2C19 | |
| SCHEMBL11590652 | 0.75 | HTR6 (0.52) | PKMCYP3A4HTR6L3MBTL1LMNA | |
| SCHEMBL9713819 | 0.74 | MAPT (0.49) | LMNAGAAALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0165422-B1 | SUBSTITUTED BIS-(4-AMINOPHENYL)-SULPHONES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1988-03-09 | — | — | EP | claimed |
| EP-0165422-A1 | Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1985-12-27 | — | — | EP | claimed |
| US-5270037-A | Use of interferon and a substance with an antimalarial activity for the treatment of malaria infections | BOEHRINGER INGELHEIM GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0490250-A2 | Use of interferon and an antimalarial agent for the treatment of malarial infections | BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) | 1992-06-17 | — | — | EP | disclosed |
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |
| EP-0165422-B1 | SUBSTITUTED BIS-(4-AMINOPHENYL)-SULPHONES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |
| EP-0165422-A1 | Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |