Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713819 | 0.91 | MAPT (0.49) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9713970 | 0.90 | MAPT (0.59) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9577459 | 0.83 | CA1 (0.47) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9713800 | 0.83 | ALDH1A1 (0.56) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9713847 | 0.80 | KMT2A (0.50) | KMT2AMEN1RAB9AALDH1A1POLB | |
| SCHEMBL10489391 | 0.78 | MAPT (0.72) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9713773 | 0.78 | KMT2A (0.56) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9713771 | 0.76 | MAPT (0.60) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9713607 | 0.75 | MAPT (0.59) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9713834 | 0.74 | L3MBTL1 (0.51) | MAPTKMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |
| EP-0165422-B1 | SUBSTITUTED BIS-(4-AMINOPHENYL)-SULPHONES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |
| EP-0165422-A1 | Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |