Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31433786 | 0.88 | IRAK4 (0.33) | CYP11B2CYP11B1CYP3A4CHRM2CHRM4 | |
| SCHEMBL2117902 | 0.75 | MAT2A (0.42) | CYP11B2CHRM1 | |
| SCHEMBL11853247 | 0.73 | TNKS (0.42) | CHRM4CHRM5CHRM1 | |
| SCHEMBL4503078 | 0.71 | MPO (0.40) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL4504709 | 0.71 | PGR (0.47) | CYP11B2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10846917 | 0.67 | NPSR1 (0.51) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3314661 | 0.66 | PGR (0.54) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3344439 | 0.66 | PGR (0.39) | — | |
| SCHEMBL9014024 | 0.65 | PRKD3 (0.40) | CYP11B2CHRM2CHRM1TOP2ATOP2B | |
| SCHEMBL606349 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370686-B1 | A process for preparing quinolone carboxylic acid intermediates | PFIZER (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5064958-A | CHEMICAL INTERMEDIATES FOR ANTIBACTERIAL COMPOUNDS | PFIZER INC. (US) | 1991-11-12 | — | — | US | disclosed |
| US-4939290-A | Bactericides | PFIZER INC. (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0370686-A2 | A process for preparing quinolone carboxylic acid intermediates | PFIZER INC. (US) | 1990-05-30 | — | — | EP | disclosed |