Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.48 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9578143 | 0.92 | MEN1 (0.61) | MEN1KMT2ACAPN1F2RL1NPC1 | |
| SCHEMBL9578198 | 0.91 | SMN1; SMN2 (0.49) | MEN1KMT2ACAPN1F2RL1NPC1 | |
| SCHEMBL9578154 | 0.82 | NFKB1 (0.61) | MEN1KMT2ALMNANFKB1NFKB2 | |
| SCHEMBL7770564 | 0.81 | KDM4E (0.43) | CAPN1NPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL29056506 | 0.81 | RXFP1 (0.45) | MEN1KMT2ACAPN1NPC1RAB9A | |
| SCHEMBL4133126 | 0.78 | RXFP1 (0.43) | MEN1KMT2ACAPN1NPC1RAB9A | |
| SCHEMBL31088170 | 0.77 | KDM4E (0.49) | MEN1KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL873598 | 0.77 | LMNA (0.55) | MEN1KMT2AF2RL1NPC1RAB9A | |
| SCHEMBL5445458 | 0.77 | KDM4E (0.49) | MEN1KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL4145981 | 0.76 | TDP1 (0.49) | MEN1KMT2ACAPN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234951-A | Anti-ulcer agent comprising chalcone derivative | TSUMURA JUNTENDO, INC. (JP) | 1993-08-10 | — | — | US | disclosed |
| US-5106871-A | Reduced side effects | TSUMURA & CO. (JP) | 1992-04-21 | — | — | US | disclosed |
| EP-0292576-A1 | ANTI-ULCEROUS AGENT CONTAINING CHALCONE DERIVATIVE AS EFFECTIVE INGREDIENT AND NOVEL CHALCONE DERIVATIVES | TSUMURA & CO. (JP) | 1988-11-30 | — | — | EP | disclosed |