Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648729 | 0.82 | DRD2 (0.64) | KCNH2HTR2ADRD2DRD4SIGMAR1 | |
| SCHEMBL3356592 | 0.81 | DRD4 (0.55) | KCNH2DRD2DRD4SIGMAR1 | |
| SCHEMBL607491 | 0.81 | DRD2 (0.56) | DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL10994399 | 0.81 | DRD2 (0.63) | KCNH2HTR2ADRD2DRD4SIGMAR1 | |
| SCHEMBL27784422 | 0.80 | DRD2 (0.62) | KCNH2DRD2DRD4 | |
| SCHEMBL6714846 | 0.79 | ALDH1A1 (0.75) | KCNH2HTR2AHTR2CSIGMAR1 | |
| SCHEMBL11100857 | 0.79 | ALDH1A1 (0.75) | KCNH2HTR2AHTR2CSIGMAR1 | |
| SCHEMBL9529266 | 0.78 | DRD2 (0.53) | KCNH2HTR2AHTR2CHRH1DRD2 | |
| SCHEMBL27827185 | 0.77 | KCNH2 (0.65) | KCNH2HTR2AHTR2CSIGMAR1 | |
| SCHEMBL30767216 | 0.76 | KCNH2 (0.90) | KCNH2HTR2ADRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5242919-A | Antiinflammatory agents or hypotensive agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| US-5055474-A | Antihypoxia, hypotensive, antiinflammatory agents; anoxia treatment | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0173331-B1 | 2,3-DIHYDRO-1H-INDENE DERIVATIVES, A PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4895847-A | ANTIHYPOXIC, ANTIINFLAMMATORY, HYPOTENSIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| US-4788130-A | ANTIHYDOXIC, HYPOTENSIVE, ANTIINFLAMMATORY AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-11-29 | — | — | US | disclosed |
| EP-0173331-A2 | 2,3-Dihydro-1H-indene derivatives, a process for preparing them and pharmaceutical compositions containing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-03-05 | — | — | EP | disclosed |