Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6151432 | 1.00 | THRB (0.43) | THRBMEN1HTTKMT2AMAPT | |
| SCHEMBL31151133 | 0.97 | THRB (0.39) | THRBMEN1HTTKMT2AMAPT | |
| SCHEMBL15922787 | 0.95 | MEN1 (0.38) | THRBMEN1HTTKMT2AMAPT | |
| SCHEMBL9444828 | 0.95 | ALDH1A1 (0.39) | THRBMEN1HTTKMT2AMAPT | |
| SCHEMBL8628650 | 0.95 | ALDH1A1 (0.39) | THRBMEN1HTTKMT2AMAPT | |
| SCHEMBL8167936 | 0.95 | — | — | |
| SCHEMBL3923662 | 0.95 | ALDH1A1 (0.39) | THRBMEN1HTTKMT2AMAPT | |
| SCHEMBL3923327 | 0.95 | ALDH1A1 (0.39) | THRBMEN1HTTKMT2AMAPT | |
| SCHEMBL3332189 | 0.92 | — | — | |
| SCHEMBL8556928 | 0.90 | ALDH1A1 (0.39) | THRBMEN1HTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |
| US-4937373-A | Substituted naphthalene carboxylic acids | HOFFMANN-LA ROCHE INC. (US) | 1990-06-26 | — | — | US | disclosed |