SCHEMBL9580856

SCHEMBL9580856

COC(=O)CCc1ccc(O)c(-n2nc3ccc(Cl)cc3n2)c1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.43
KDM4E B2RXH2 2/20 0.43
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
RXFP1 Q9HBX9 1/20 0.39
MAPT P10636 3/20 0.39
TP53 P04637 1/20 0.39
ALOX5 P09917 1/20 0.38
OR51E2 Q9H255 1/20 0.38
NPC1 O15118 1/20 0.38
LMNA P02545 1/20 0.38
RAB9A P51151 1/20 0.38
P2RX3 P56373 1/20 0.37
POLB P06746 1/20 0.37
CCR9 P51686 2/20 0.37
APP P05067 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5693424 0.87 LMNA (0.51) KDM4ECYP11B1CYP11B2MAPTALOX5
SCHEMBL8647506 0.86 FFAR1 (0.42) KDM4ERXFP1MAPTTP53NPC1
SCHEMBL29142799 0.86 KDM4E (0.47) EGFRKDM4ECYP11B1CYP11B2RXFP1
SCHEMBL20622007 0.85 RPS6KB2 (0.45) KDM4EALOX5OR51E2NPC1LMNA
SCHEMBL5693442 0.84 FFAR4 (0.40) KDM4EALOX5OR51E2NPC1LMNA
SCHEMBL9638776 0.82 NPC1 (0.43) KDM4ERXFP1MAPTTP53ALOX5
SCHEMBL29664175 0.82 GAA (0.42) EGFRKDM4ECYP11B1CYP11B2LMNA
SCHEMBL78795 0.82 GAA (0.42) EGFRKDM4ECYP11B1CYP11B2LMNA
SCHEMBL7566832 0.81 MAPT (0.42) KDM4ERXFP1MAPTTP53ALOX5
SCHEMBL20591058 0.81 KDM4E (0.41) EGFRKDM4ECYP11B1CYP11B2RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0293871-B1 LIGHT STABILIZED, STARSHAPED MICROPARTICLES CIBA-GEIGY AG (CH) 1993-03-17 EP disclosed