Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964074 | 0.87 | KMT2A (0.59) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL8964071 | 0.87 | KMT2A (0.59) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL8216687 | 0.80 | LMNA (0.73) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL8216686 | 0.80 | LMNA (0.73) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL8216684 | 0.80 | LMNA (0.73) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL8964067 | 0.79 | KMT2A (0.57) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL8964063 | 0.79 | KMT2A (0.57) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL411835 | 0.78 | HTR1A (0.56) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12136814 | 0.77 | LMNA (0.73) | MAPTLMNARECQLALDH1A1POLB | |
| SCHEMBL13044233 | 0.74 | SRC (0.63) | MAPTLMNARECQLALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246943-A | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties | WARNER-LAMBERT COMPANY (US) | 1993-09-21 | — | — | US | disclosed |