Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581423 | 0.93 | TDP1 (0.54) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581842 | 0.90 | HTR1A (0.52) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581469 | 0.89 | TDP1 (0.50) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL10355145 | 0.88 | TDP1 (0.59) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581574 | 0.85 | KDM4E (0.43) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9582247 | 0.84 | TDP1 (0.65) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581497 | 0.82 | TDP1 (0.65) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581439 | 0.81 | TDP1 (0.61) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581735 | 0.79 | SIGMAR1 (0.48) | KMT2ACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL9582214 | 0.79 | HTR7 (0.43) | TDP1KDM4EALOX15APEX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |