SCHEMBL958405

SCHEMBL958405

CCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 20/20 1.00
ADORA2A P29274 20/20 1.00
ADORA1 P30542 19/20 1.00
ADORA2B P29275 17/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2283833 0.95 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL2284068 0.94 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL2284382 0.92 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL12375770 0.91 ADORA3 (0.88) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL13746388 0.91 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL1389191 0.91 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL4759873 0.91 ADORA3 (0.85) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL1389184 0.90 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL2283773 0.89 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B
SCHEMBL4758021 0.89 ADORA3 (1.00) ADORA3ADORA2AADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117321080-A Combination therapy using anti-CD 38 antibodies and PARP or adenosine receptor inhibitors 詹森生物科技公司 2023-12-29 CN claimed
EP-4294844-A1 COMBINATION THERAPIES WITH ANTI-CD38 ANTIBODIES AND PARP OR ADENOSINE RECEPTOR INHIBITORS Janssen Biotech, Inc. (US) 2023-12-27 EP claimed
US-20220275090-A1 Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors JANSSEN BIOTECH, INC. 2022-09-01 US claimed
WO-2022175920-A1 COMBINATION THERAPIES WITH ANTI-CD38 ANTIBODIES AND PARP OR ADENOSINE RECEPTOR INHIBITORS JANSSEN BIOTECH, INC. (US) 2022-08-25 WO claimed
US-20110190324-A1 METHODS OF TREATING ATHEROSCLEROSIS MCNC ENTERPRISE FUND, L.P. 2011-08-04 US claimed
US-7271171-B2 Adenosine A3 receptor modulators KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2007-09-18 US claimed
US-20060040959-A1 Adenosine A3 receptor modulators KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2006-02-23 US claimed
EP-1499614-A1 ADENOSINE A3 RECEPTOR MODULATORS King Pharmaceuticals Research and Development Inc. (US) 2005-01-26 EP claimed
WO-2003095457-A1 ADENOSINE A3 RECEPTOR MODULATORS KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2003-11-20 WO claimed
US-20030144266-A1 Adenosine A3 receptor modulators KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2003-07-31 US claimed
US-6448253-B1 Adenosine A3 receptor modulators KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2002-09-10 US claimed
US-12569445-B2 Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof HALOZYME HYPERCON, INC. (US) 2026-03-10 US disclosed
US-12558323-B2 Particle formation and morphology ELEKTROFI, INC. (US) 2026-02-24 US disclosed
US-20260007615-A1 PARTICLES COMPRISING A THERAPEUTIC OR DIAGNOSTIC AGENT AND SUSPENSIONS AND METHODS OF USE THEREOF ELEKTROFI INC (US) 2026-01-08 US disclosed
US-20260000616-A1 METHODS OF FORMING PARTICLES BY CONTINUOUS DROPLET FORMATION AND DEHYDRATION ELEKTROFI INC (US) 2026-01-01 US disclosed
US-20030144266-A1 Adenosine A3 receptor modulators KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2003-07-31 US disclosed
US-6448253-B1 Adenosine A3 receptor modulators KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2002-09-10 US disclosed
US-6407236-B1 TUMOR DIAGNOSIS; ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; ANTIDEPRESSANTS MEDCO RESEARCH, INC. 2002-06-18 US disclosed
US-6326390-B1 ADMINISTERING ADENOSINE A1 KING PHARMACEUTICALS RESEACH AND DEVELOPMENT, INC. 2001-12-04 US disclosed
WO-2000010391-A1 THE USE OF ADENOSINE A3 RECEPTOR ANTAGONISTS TO INHIBIT TUMOR GROWTH MEDCO RESEARCH, INC. (US) 2000-03-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260000616-A1 METHODS OF FORMING PARTICLES BY CONTINUOUS DROPLET FORMATION AND DEHYDRATION ALB, TNF, TTR ADORA3 4580/4885ADORA2A 3439/4885ADORA1 4507/4885
US-20220275090-A1 Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors CD38, PARP1, PARP11 ADORA3 23/4885ADORA2A 16/4885ADORA1 25/4885
US-12569445-B2 Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof ALB, S100P, S100A8 ADORA3 1969/4885ADORA2A 2833/4885ADORA1 2871/4885
US-20110190324-A1 METHODS OF TREATING ATHEROSCLEROSIS ADORA3, ADORA2A, ADORA1 ADORA3 1/4885ADORA2A 2/4885ADORA1 3/4885
US-12558323-B2 Particle formation and morphology CD63, EXOSC10, EPCAM ADORA3 3873/4885ADORA2A 3001/4885ADORA1 3176/4885
US-20260007615-A1 PARTICLES COMPRISING A THERAPEUTIC OR DIAGNOSTIC AGENT AND SUSPENSIONS AND METHODS OF USE THEREOF FLNB, FLNA, FUS ADORA3 3107/4885ADORA2A 3104/4885ADORA1 2292/4885
US-20060040959-A1 Adenosine A3 receptor modulators ADORA3, ADORA2A, ADORA1 ADORA3 1/4885ADORA2A 2/4885ADORA1 3/4885
US-20030144266-A1 Adenosine A3 receptor modulators ADORA3, ADORA2A, ADORA1 ADORA3 1/4885ADORA2A 2/4885ADORA1 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.