Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881610 | 0.73 | FOLH1 (0.55) | FOLH1PTGDR2ALDH1A1SMN1; SMN2PLA2G2A | |
| SCHEMBL13752240 | 0.73 | PRKDC (0.57) | POLBPRKDCALDH1A1SMN1; SMN2ATM | |
| SCHEMBL8173620 | 0.72 | FOLH1 (0.64) | POLBFOLH1PTGDR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL9584666 | 0.71 | PLA2G2A (0.55) | FOLH1PTGDR2ALDH1A1SMN1; SMN2PLA2G2A | |
| SCHEMBL4780401 | 0.70 | PLA2G2A (0.54) | FOLH1PTGDR2ALDH1A1SMN1; SMN2PLA2G2A | |
| SCHEMBL9584407 | 0.70 | FOLH1 (0.52) | POLBFOLH1PTGDR2ALDH1A1SMN1; SMN2 | |
| Water SCHEMBL9584494 | 0.70 | PTGDR2 (0.51) | FOLH1PTGDR2PLA2G2AGFERHDAC1 | |
| Water SCHEMBL9583966 | 0.70 | GFER (0.51) | POLBFOLH1PTGDR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8387165 | 0.70 | KMT2A (0.55) | POLBPRKDCALDH1A1NPC1SMN1; SMN2 | |
| Water SCHEMBL9584611 | 0.69 | FOLH1 (0.48) | POLBFOLH1PTGDR2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5245046-A | α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0375133-A1 | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |
| WO-1990005721-A1 | ALPHA-AMINO-INDOLE-3-ACETIC ACIDS USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | disclosed |