⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723992 | 0.84 | SHBG (0.31) | — | |
| SCHEMBL9625475 | 0.84 | SHBG (0.31) | — | |
| SCHEMBL565199 | 0.78 | ALDH1A1 (0.36) | — | |
| SCHEMBL487249 | 0.72 | CYP2D6 (0.33) | — | |
| SCHEMBL486945 | 0.70 | CYP2D6 (0.36) | — | |
| SCHEMBL486973 | 0.70 | CYP2D6 (0.36) | — | |
| SCHEMBL5410724 | 0.69 | — | — | |
| SCHEMBL5411605 | 0.58 | — | — | |
| SCHEMBL22598355 | 0.55 | — | — | |
| SCHEMBL5211752 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2754654-B1 | METHOD FOR PRODUCING COUMARIN DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-05-30 | — | — | EP | disclosed |
| US-9133174-B2 | Method for producing coumarin derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-09-15 | — | — | US | disclosed |
| US-20140213786-A1 | Method for Producing Coumarin Derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2014-07-31 | — | — | US | disclosed |
| US-8569378-B2 | p27 protein inducer | Sakai, Toshiyuki (JP) | 2013-10-29 | — | — | US | disclosed |
| US-8278465-B2 | Coumarin derivative having antitumor activity | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-10-02 | — | — | US | disclosed |
| EP-1982982-B1 | NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2012-09-26 | — | — | EP | disclosed |
| CN-101384577-B | Novel coumarin derivative having antitumor activity | CHUGAI PHARMACEUTICAL CO LTD | 2011-10-19 | — | — | CN | disclosed |
| US-20110092700-A1 | Novel Coumarin Derivative Having Antitumor Activity | IIKURA HITOSHI | 2011-04-21 | — | — | US | disclosed |
| US-7897792-B2 | Coumarin derivative having antitumor activity | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-03-01 | — | — | US | disclosed |
| US-20110009398-A1 | p27 Protein Inducer | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-01-13 | — | — | US | disclosed |
| EP-2172198-A1 | p27 PROTEIN INDUCER | Chugai Seiyaku Kabushiki Kaisha (JP) | 2010-04-07 | — | — | EP | disclosed |
| US-20100004233-A1 | NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-01-07 | — | — | US | disclosed |
| CN-101384577-A | Novel coumarin derivative having antitumor activity | SAKAI TOSHIYUKI (JP) | 2009-03-11 | — | — | CN | disclosed |
| EP-1982982-A1 | NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-10-22 | — | — | EP | disclosed |