Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.40 |
| ▸ | DRD3 | P35462 | 7/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150944 | 0.91 | MAP3K14 (0.47) | DRD2DRD3ABCC9ABCC8KCNJ11 | |
| SCHEMBL4133966 | 0.78 | MAP3K14 (0.59) | DRD2DRD3CYP11B1CYP11B2AURKA | |
| SCHEMBL4140398 | 0.78 | MAP3K14 (0.59) | DRD2DRD3CYP11B1CYP11B2AURKA | |
| SCHEMBL8350459 | 0.78 | MAP3K14 (0.42) | DRD2DRD3DYRK1AMAP3K14CYP1A2 | |
| SCHEMBL9585396 | 0.77 | DRD2 (0.38) | DRD2DRD3LRRK2ABCC9ABCC8 | |
| SCHEMBL9585392 | 0.77 | DRD2 (0.38) | DRD2DRD3LRRK2ABCC9ABCC8 | |
| SCHEMBL9585384 | 0.77 | DRD2 (0.38) | DRD2DRD3LRRK2ABCC9ABCC8 | |
| SCHEMBL2114929 | 0.76 | ADRA2A (0.45) | DRD2DRD3MAP3K14CYP2D6LMNA | |
| SCHEMBL1266045 | 0.76 | DRD2 (0.42) | DRD2DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL29243618 | 0.76 | DRD2 (0.42) | DRD2DRD3CYP11B1CYP11B2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194442-A | 2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceutical products based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-16 | — | — | US | disclosed |
| EP-0360131-A1 | 2,3,4,5-Tetrahydro-1-benzoxepines, method for their preparation, their use and pharmaceutical compositions based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-03-28 | — | — | EP | disclosed |