SCHEMBL958594

SCHEMBL958594

Cc1cc(C#N)cc2c(=O)oc(-c3cc(Cl)nn3-c3ncccc3Cl)nc12

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 1/20 0.33
▸ CYP17A1 P05093 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32
▸ ELANE P08246 2/20 0.31
▸ PIM1 P11309 1/20 0.31
▸ CSNK2A2 P19784 1/20 0.31
▸ CSNK2B P67870 1/20 0.31
▸ PIM3 Q86V86 1/20 0.31
▸ PIM2 Q9P1W9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL958508 0.92 PIM1 (0.34) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL31059998 0.91 DHODH (0.33) DHODHCYP17A1CYP1A2ELANEPIM1
SCHEMBL465751 0.91 DHODH (0.41) DHODHCYP17A1CYP1A2ELANEPIM1
SCHEMBL29669886 0.91 DHODH (0.41) DHODHCYP17A1CYP1A2ELANEPIM1
SCHEMBL30234217 0.90 DHODH (0.33) DHODHCYP17A1CYP1A2ELANE
SCHEMBL15972086 0.90 DHODH (0.33) DHODHCYP17A1CYP1A2ELANE
SCHEMBL959311 0.89 PDPK1 (0.35) DHODHELANE
SCHEMBL15971908 0.89 LIMK1 (0.32) DHODHCYP17A1CYP1A2
SCHEMBL1762432 0.89 CYP17A1 (0.34) DHODHCYP17A1CYP1A2ELANE
SCHEMBL31059972 0.88 KLK7 (0.34) DHODHCYP17A1CYP1A2ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9161540-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-10-20 — — US disclosed
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-25 — — US disclosed
EP-2264022-B1 Cyano anthranilamide insecticides DU PONT (US) 2013-07-24 — — EP disclosed
US-8475819-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-02 — — US disclosed
EP-1599463-B1 CYANO ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-06-05 — — EP disclosed
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-12-29 — — US disclosed
US-7875634-B2 contain 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-pyrazole-5-carboxamide; for controlling invertebrate pests in both agronomic and nonagronomic environments E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-01-25 — — US disclosed
EP-2264022-A1 Cyano anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2010-12-22 — — EP disclosed
US-20070264299-A1 Cyano anthranilamide insecticides FMC CORPORATION 2007-11-15 — — US disclosed
US-7247647-B2 Cyano anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-07-24 — — US disclosed
US-20060111403-A1 Cyano anthranilamide insecticides FMC CORPORATION 2006-05-25 — — US disclosed
EP-1599463-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. du Pont de Nemours and Company (US) 2005-11-30 — — EP disclosed
WO-2004067528-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-08-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060111403-A1 Cyano anthranilamide insecticides C1S, C5, CBR3 DHODH 1074/4885CYP17A1 3340/4885CYP1A2 686/4885
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R DHODH 1187/4885CYP17A1 3659/4885CYP1A2 621/4885
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R DHODH 1187/4885CYP17A1 3659/4885CYP1A2 621/4885
US-20070264299-A1 Cyano anthranilamide insecticides C1S, CBR3, C5 DHODH 1499/4885CYP17A1 3841/4885CYP1A2 738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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