SCHEMBL959311

SCHEMBL959311

Cc1cc(C#N)cc2c(=O)oc(-c3cc(C(F)(F)F)nn3-c3ncccc3Cl)nc12

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PDPK1 O15530 1/20 0.35
▸ OPRL1 P41146 1/20 0.33
▸ RXRA P19793 1/20 0.33
▸ NR1H2 P55055 1/20 0.33
▸ NR1H3 Q13133 1/20 0.33
▸ KDM4E B2RXH2 2/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ CARM1 Q86X55 1/20 0.32
▸ PTGS2 P35354 1/20 0.32
▸ SCN9A Q15858 1/20 0.32
▸ NR3C2 P08235 1/20 0.32
▸ MAPT P10636 2/20 0.32
▸ ELANE P08246 1/20 0.31
▸ MAT2A P31153 1/20 0.31
▸ HSD11B1 P28845 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ DHODH Q02127 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL499517 0.90 KDM4E (0.34) OPRL1RXRANR1H2NR1H3KDM4E
SCHEMBL950884 0.90 KDM4E (0.34) OPRL1RXRANR1H2NR1H3KDM4E
SCHEMBL30466609 0.90 MAPT (0.35) OPRL1RXRANR1H2NR1H3KDM4E
SCHEMBL25235198 0.90 MAPT (0.35) OPRL1RXRANR1H2NR1H3KDM4E
SCHEMBL950989 0.89 KDM4E (0.34) OPRL1RXRANR1H2NR1H3KDM4E
Ammonia Solution, Strong SCHEMBL25275402 0.89 MAPT (0.35) OPRL1RXRANR1H2NR1H3KDM4E
SCHEMBL30466601 0.89 MAPT (0.35) OPRL1RXRANR1H2NR1H3KDM4E
SCHEMBL958594 0.89 DHODH (0.33) ELANEDHODH
SCHEMBL951078 0.88 DHODH (0.34) OPRL1RXRANR1H2NR1H3KDM4E
SCHEMBL31059998 0.87 DHODH (0.33) ELANEDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9161540-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-10-20 — — US disclosed
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-25 — — US disclosed
EP-2264022-B1 Cyano anthranilamide insecticides DU PONT (US) 2013-07-24 — — EP disclosed
US-8475819-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-02 — — US disclosed
EP-1599463-B1 CYANO ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-06-05 — — EP disclosed
EP-2564706-A1 Anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2013-03-06 — — EP disclosed
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-12-29 — — US disclosed
US-7875634-B2 contain 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-pyrazole-5-carboxamide; for controlling invertebrate pests in both agronomic and nonagronomic environments E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-01-25 — — US disclosed
EP-2264022-A1 Cyano anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2010-12-22 — — EP disclosed
EP-1871760-B1 CYANO ANTHRANILAMIDE INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-08-11 — — EP disclosed
US-20080182750-A1 Cyano Anthranilamide Insecticides SYNGENTA CROP PROTECTION, INC. (US) 2008-07-31 — — US disclosed
EP-1871760-A1 CYANO ANTHRANILAMIDE INSECTICIDES Syngeta Participations AG (CH) 2008-01-02 — — EP disclosed
US-20070264299-A1 Cyano anthranilamide insecticides FMC CORPORATION 2007-11-15 — — US disclosed
EP-1812421-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-08-01 — — EP disclosed
US-7247647-B2 Cyano anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-07-24 — — US disclosed
WO-2006111341-A1 CYANO ANTHRANILAMIDE INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2006-10-26 — — WO disclosed
WO-2006055922-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-05-26 — — WO disclosed
US-20060111403-A1 Cyano anthranilamide insecticides FMC CORPORATION 2006-05-25 — — US disclosed
EP-1599463-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. du Pont de Nemours and Company (US) 2005-11-30 — — EP disclosed
WO-2004067528-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-08-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060111403-A1 Cyano anthranilamide insecticides C1S, C5, CBR3 PDPK1 4593/4885OPRL1 1677/4885RXRA 3569/4885
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R PDPK1 4495/4885OPRL1 1742/4885RXRA 3400/4885
US-20080182750-A1 Cyano Anthranilamide Insecticides CRY1, CRYAA, ALDH7A1 PDPK1 2389/4885OPRL1 3722/4885RXRA 2985/4885
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R PDPK1 4495/4885OPRL1 1742/4885RXRA 3400/4885
US-20070264299-A1 Cyano anthranilamide insecticides C1S, CBR3, C5 PDPK1 4450/4885OPRL1 1831/4885RXRA 3187/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback