Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585857 | 0.86 | TARBP2 (0.56) | LMNAPRKCZALDH1A1KDM4EHPGD | |
| SCHEMBL22230646 | 0.86 | TARBP2 (0.56) | KDM4EMEN1KMT2AGABRA2GABRB2 | |
| SCHEMBL892693 | 0.86 | TARBP2 (0.52) | LMNAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9587202 | 0.84 | TRPM8 (0.50) | LMNAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL4060790 | 0.78 | ELANE (0.46) | LMNAALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL1776614 | 0.78 | KDM4E (0.51) | LMNAPRKCZALDH1A1KDM4EHPGD | |
| SCHEMBL27809428 | 0.77 | MAPK14 (0.49) | KMT2AMAPK14GCGRPTGS2 | |
| Phenylacetylene SCHEMBL1704028 | 0.77 | TARBP2 (0.44) | LMNAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9586903 | 0.76 | L3MBTL1 (0.50) | ALDH1A1GABRA2GABRB2TRPM8MAPT | |
| SCHEMBL27646217 | 0.76 | PTGS2 (0.49) | MAPK14MAPK1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204482-A | Ethylenediamine monoamide heteroaryl derivatives | HOFFMAN-LAROCHE INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5011849-A | Monoamine oxidase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1991-04-30 | — | — | US | disclosed |