Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9588721 | 0.94 | MEN1 (0.54) | MEN1KMT2ACHRM1ALDH1A1KDM4E | |
| Febuverine SCHEMBL2110466 | 0.90 | ALDH1A1 (0.56) | MEN1KMT2ACHRM1ALDH1A1KDM4E | |
| Febuverine SCHEMBL9588720 | 0.89 | ALDH1A1 (0.58) | MEN1KMT2ACHRM1ALDH1A1KDM4E | |
| SCHEMBL9589619 | 0.82 | GAA (0.52) | MEN1KMT2AHRH1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9604865 | 0.81 | GAA (0.51) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL9588306 | 0.80 | ALDH1A1 (0.56) | CHRM1ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL9604696 | 0.79 | ALDH1A1 (0.59) | CHRM1ALDH1A1GAA | |
| SCHEMBL9589633 | 0.77 | POLB (0.56) | KMT2AHRH1 | |
| SCHEMBL9588549 | 0.77 | SLC6A4 (0.48) | — | |
| SCHEMBL9590105 | 0.77 | ALDH1A1 (0.50) | MEN1KMT2AHRH1CHRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190946-A | Piperazine compounds restore sensitivity to drug resistant cancer cells | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0443569-A2 | Diamine derivatives and their use in oncology | F. HOFFMANN-LA ROCHE AG (CH) | 1991-08-28 | — | — | EP | disclosed |