Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 2/20 | 0.33 |
| ▸ | CCR8 | P51685 | 2/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524431 | 0.83 | NPC1 (0.40) | NPC1L3MBTL1HSP90AA1NOS3NOS1 | |
| SCHEMBL4801381 | 0.74 | L3MBTL1 (0.31) | L3MBTL1 | |
| SCHEMBL8829204 | 0.74 | CYP1A2 (0.30) | — | |
| SCHEMBL8829283 | 0.71 | GRM5 (0.32) | L3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL2094224 | 0.69 | MAPT (0.33) | L3MBTL1MAPTKDM4E | |
| SCHEMBL211308 | 0.69 | KDM4E (0.38) | NPC1MAPTKDM4ECYP2A6RAB9A | |
| SCHEMBL8829129 | 0.69 | L3MBTL1 (0.36) | NPC1L3MBTL1MAPTKDM4EHTT | |
| SCHEMBL8829270 | 0.66 | GAA (0.31) | MAPTKDM4ESMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3829173 | 0.65 | L3MBTL1 (0.31) | L3MBTL1 | |
| SCHEMBL25431743 | 0.64 | ALDH1A1 (0.36) | L3MBTL1HSP90AA1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248681-A | DIHYDROPYRIDINE ANTIALLERGY AGENTS | PFIZER INC. (US) | 1993-09-28 | — | — | US | claimed |
| EP-0467895-A1 | DIHYDROPYRIDINE ANTIALLERGY AGENTS | Pfizer Limited (GB) | 1992-01-29 | — | — | EP | claimed |
| EP-0310386-B1 | 4-ARYL-5-CARBAMOYL-1,4-DIHYDROPYRIDINES | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | claimed |
| WO-1990012015-A1 | DIHYDROPYRIDINE ANTIALLERGY AGENTS | PFIZER LIMITED (GB) | 1990-10-18 | — | — | WO | claimed |
| EP-0365140-A1 | 1,4-Dihydropyridine derivatives | Pfizer Limited (GB) | 1990-04-25 | — | — | EP | claimed |
| EP-0310386-A2 | 4-Aryl-5-carbamoyl-1,4-dihydropyridines | Pfizer Limited (GB) | 1989-04-05 | — | — | EP | claimed |
| US-5248681-A | DIHYDROPYRIDINE ANTIALLERGY AGENTS | PFIZER INC. (US) | 1993-09-28 | — | — | US | disclosed |
| US-5214044-A | Antiallergens | PFIZER INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5149814-A | Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds | PFIZER INC (US) | 1992-09-22 | — | — | US | disclosed |
| US-5120747-A | Antiallergens, antiinflammatory agent | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5070205-A | Chemical intermediate for anticoagulants | PFIZER INC. (US) | 1991-12-03 | — | — | US | disclosed |
| EP-0310386-B1 | 4-ARYL-5-CARBAMOYL-1,4-DIHYDROPYRIDINES | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5063237-A | Antiallergens and antiinflammatory agents | PFIZER INC. (US) | 1991-11-05 | — | — | US | disclosed |
| WO-1990012015-A1 | DIHYDROPYRIDINE ANTIALLERGY AGENTS | PFIZER LIMITED (GB) | 1990-10-18 | — | — | WO | disclosed |
| US-4935430-A | Platelet activating factor antagonists | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0365140-A1 | 1,4-Dihydropyridine derivatives | Pfizer Limited (GB) | 1990-04-25 | — | — | EP | disclosed |
| EP-0310386-A2 | 4-Aryl-5-carbamoyl-1,4-dihydropyridines | Pfizer Limited (GB) | 1989-04-05 | — | — | EP | disclosed |