Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DNM2 | P50570 | 7/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15585264 | 0.89 | TLR8 (0.51) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL12330672 | 0.82 | DNM2 (0.53) | TLR8ALDH1A1DNM2ESR1KMT2A | |
| SCHEMBL20476323 | 0.82 | MAPT (0.50) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL16608857 | 0.81 | ALDH1A1 (0.73) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL22228324 | 0.81 | ALDH1A1 (0.54) | TLR8ALDH1A1MAPK1HTTESR1 | |
| SCHEMBL9884955 | 0.81 | SMN1; SMN2 (0.49) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL20434306 | 0.79 | TLR8 (1.00) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL9590680 | 0.79 | TLR8 (0.66) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL2578650 | 0.79 | KMT2A (0.47) | TLR8ALDH1A1LMNATP53TSHR | |
| SCHEMBL9313985 | 0.79 | TLR8 (0.65) | TLR8ALDH1A1LMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250548-A | Treating hypertension, heart failure | ABBOTT LABORATORIES (US) | 1993-10-05 | — | — | US | disclosed |