Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | CETP | P11597 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9593156 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL9584286 | 0.79 | — | — | |
| SCHEMBL29954342 | 0.72 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL9592123 | 0.71 | — | — | |
| SCHEMBL6928223 | 0.70 | ALDH1A1 (0.45) | ALDH1A1TLR7LMNAMAPK1 | |
| SCHEMBL6922966 | 0.68 | ALDH1A1 (0.43) | ALDH1A1TLR7LMNAMAPK1 | |
| SCHEMBL8532701 | 0.67 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL8536161 | 0.66 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL8536407 | 0.64 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPK1 | |
| Butylbenzyl SCHEMBL4983622 | 0.63 | CETP (0.64) | CETPALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208235-A | Phosphonic or phosphinic acid derivatives as inhibitors of angiotnesin II for cardiovascular disorders and hypotensives | E. R. SQUIBB & SONS, INC. (US) | 1993-05-04 | — | — | US | disclosed |