Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590597 | 0.81 | DRD4 (0.67) | DRD4MCHR1ALDH1A1EPHX1NPSR1 | |
| SCHEMBL10964860 | 0.73 | DRD4 (0.53) | DRD4MCHR1ALDH1A1EPHX1NPSR1 | |
| SCHEMBL16322087 | 0.72 | DRD4 (0.69) | DRD4EPHX1RAB9ANPSR1NPC1 | |
| SCHEMBL4502456 | 0.71 | DRD4 (0.67) | DRD4EPHX1RAB9ANPC1MEN1 | |
| SCHEMBL10965667 | 0.71 | DRD4 (0.58) | DRD4MCHR1ALDH1A1EPHX1 | |
| SCHEMBL13801318 | 0.70 | DRD4 (0.66) | DRD4MCHR1EPHX1RAB9ANPSR1 | |
| SCHEMBL18389994 | 0.70 | HRH3 (0.67) | DRD4MCHR1ALDH1A1RAB9ANPSR1 | |
| Panuramine SCHEMBL2037759 | 0.68 | MCHR1 (0.83) | DRD4MCHR1MEN1KMT2A | |
| SCHEMBL20382014 | 0.68 | NPSR1 (0.59) | DRD4MCHR1ALDH1A1RAB9ANPSR1 | |
| Panuramine SCHEMBL9749426 | 0.67 | MCHR1 (0.81) | DRD4MCHR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212179-A | Antidepressants | JOHN WYETH AND BROTHER LIMITED (GB) | 1993-05-18 | — | — | US | disclosed |
| US-4985438-A | PSYCHOTROPIC ACTIVITY, ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LIMITED (GB) | 1991-01-15 | — | — | US | disclosed |
| US-4806552-A | ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LIMITED (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4722930-A | ANTIDEPRESSANTS | JOHN WYETH AND BROTHER LIMITED (GB) | 1988-02-02 | — | — | US | disclosed |
| US-4563466-A | ANTISEROTONINE | JOHN WYETH & BROTHER LIMITED (GB) | 1986-01-07 | — | — | US | disclosed |
| US-4426387-A | Piperid-4-yl ureas and thio ureas used as anti-depressant agents | JOHN WYETH & BROTHER LTD. (GB) | 1984-01-17 | — | — | US | disclosed |