Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.67 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590759 | 0.88 | DRD4 (0.75) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL11337873 | 0.85 | DRD4 (0.71) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL9593042 | 0.84 | DRD4 (0.72) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL9591635 | 0.81 | DRD4 (0.78) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL9592451 | 0.81 | DRD4 (0.71) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL8786936 | 0.81 | DRD4 (1.00) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| Panuramine SCHEMBL2037759 | 0.81 | MCHR1 (0.83) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL9590922 | 0.81 | DRD4 (0.77) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL9591654 | 0.80 | DRD4 (0.84) | DRD4MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL9593555 | 0.80 | DRD4 (0.76) | DRD4MCHR1SIGMAR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212179-A | Antidepressants | JOHN WYETH AND BROTHER LIMITED (GB) | 1993-05-18 | — | — | US | disclosed |
| US-4985438-A | PSYCHOTROPIC ACTIVITY, ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LIMITED (GB) | 1991-01-15 | — | — | US | disclosed |
| US-4806552-A | ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LIMITED (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4722930-A | ANTIDEPRESSANTS | JOHN WYETH AND BROTHER LIMITED (GB) | 1988-02-02 | — | — | US | disclosed |
| US-4563466-A | ANTISEROTONINE | JOHN WYETH & BROTHER LIMITED (GB) | 1986-01-07 | — | — | US | disclosed |
| US-4426387-A | Piperid-4-yl ureas and thio ureas used as anti-depressant agents | JOHN WYETH & BROTHER LTD. (GB) | 1984-01-17 | — | — | US | disclosed |