Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.71 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.49 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590759 | 0.91 | DRD4 (0.75) | DRD4MCHR1MEN1KMT2ACCR3 | |
| SCHEMBL11065384 | 0.85 | KMT2A (0.69) | DRD4KMT2ACCR3SMN1; SMN2POLB | |
| SCHEMBL9592476 | 0.85 | DRD4 (0.67) | DRD4MCHR1MEN1KMT2ACCR3 | |
| SCHEMBL9593263 | 0.84 | DRD4 (0.79) | DRD4MCHR1MEN1KMT2ACCR3 | |
| SCHEMBL9591635 | 0.84 | DRD4 (0.78) | DRD4MCHR1MEN1KMT2ALMNA | |
| SCHEMBL9592451 | 0.84 | DRD4 (0.71) | DRD4MCHR1MEN1KMT2ACCR3 | |
| SCHEMBL8786936 | 0.83 | DRD4 (1.00) | DRD4MCHR1MEN1KMT2ALMNA | |
| Panuramine SCHEMBL2037759 | 0.83 | MCHR1 (0.83) | DRD4MCHR1MEN1KMT2ACCR3 | |
| SCHEMBL9590922 | 0.83 | DRD4 (0.77) | DRD4MCHR1MEN1KMT2ACCR3 | |
| SCHEMBL9591654 | 0.83 | DRD4 (0.84) | DRD4MCHR1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035374-A2 | Piperidyl - urea, - thiourea and - guanidine derivatives, and intermediates therefor, processes for preparing them and pharmaceutical compositions containing the derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1981-09-09 | — | — | EP | claimed |