Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.47 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592698 | 0.93 | KDM1A (0.53) | HDAC1HDAC6PHLPP2KDM1APOLB | |
| SCHEMBL9594191 | 0.93 | KDM1A (0.59) | HDAC1HDAC6PHLPP2KDM1APOLB | |
| SCHEMBL9594286 | 0.92 | HDAC1 (0.52) | HDAC1HDAC6PHLPP2KDM1APOLB | |
| SCHEMBL9594422 | 0.92 | HDAC1 (0.52) | HDAC1HDAC6PHLPP2KDM1APOLB | |
| SCHEMBL9593647 | 0.92 | KDM1A (0.50) | KDM1APOLBCSF1RMAPTTP53 | |
| SCHEMBL9594305 | 0.91 | PHLPP2 (0.61) | HDAC1HDAC6PHLPP2KDM1APOLB | |
| SCHEMBL9594824 | 0.88 | SLC2A1 (0.48) | HDAC1HDAC6KDM1AKMT2AMAP2K1 | |
| SCHEMBL9595381 | 0.88 | HDAC1 (0.54) | HDAC1HDAC6PHLPP2KDM1APOLB | |
| SCHEMBL9595086 | 0.88 | TOP2A (0.58) | HDAC1HDAC6PHLPP2KDM1APOLB | |
| SCHEMBL9594504 | 0.87 | KDM1A (0.69) | HDAC1HDAC6PHLPP2KDM1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |