Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007343 | 0.80 | KMT2A (0.44) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL11451916 | 0.78 | GPR35 (0.50) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL11451918 | 0.78 | GPR35 (0.50) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL7423726 | 0.78 | KMT2A (0.42) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL11493131 | 0.76 | KMT2A (0.41) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL11451379 | 0.73 | GPR35 (0.45) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL30844063 | 0.73 | MEN1 (0.44) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL1021883 | 0.73 | MEN1 (0.44) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL11410883 | 0.73 | GPR35 (0.45) | KMT2AKDM4EMAPTMEN1GAA | |
| SCHEMBL3253975 | 0.72 | HSD17B10 (0.47) | KMT2AKDM4EMAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5216157-A | Useful for preparation of nifedipine a calcium antagonist used in treatment of hypertension | EGIS GYOGYSZERGYAR (HU) | 1993-06-01 | — | — | US | disclosed |
| US-5126457-A | Reacting nitrophenyl imines or diimines with methyl acetoacetate and amino or ammonium compounds yields high purity Nifedipine | EGIS GYOGYSZERGYAR (HU) | 1992-06-30 | — | — | US | disclosed |