Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 8/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9593901 | 0.85 | ADRB1 (1.00) | ADRB1SLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL9670487 | 0.78 | ADRB1 (0.74) | ADRB1SLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL9595403 | 0.77 | ADRB1 (0.62) | ADRB1HPGD | |
| SCHEMBL24918358 | 0.73 | SLC6A4 (0.64) | ADRB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9594188 | 0.73 | ADRB1 (1.00) | ADRB1KEAP1HTR6 | |
| SCHEMBL7149297 | 0.72 | SLC6A2 (0.69) | ADRB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10683759 | 0.71 | ADRB1 (0.56) | ADRB1SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL9670493 | 0.70 | ADRB1 (0.56) | ADRB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11267479 | 0.69 | SLC6A2 (0.66) | ADRB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20141290 | 0.69 | SLC6A4 (0.69) | ADRB1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491709-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-07-01 | — | — | EP | claimed |
| US-5051422-A | 2-substituted-1(4)-aryl piperazines and the process for their preparation | SCHERING AG (DE) | 1991-09-24 | — | — | US | claimed |
| WO-1991004250-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-04-04 | — | — | WO | claimed |
| US-5223623-A | 2-substituted-1(4)-aryl piperazines and the process for their preparation | SCHERING AG (DE) | 1993-06-29 | — | — | US | disclosed |
| EP-0491709-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-07-01 | — | — | EP | disclosed |
| US-5051422-A | 2-substituted-1(4)-aryl piperazines and the process for their preparation | SCHERING AG (DE) | 1991-09-24 | — | — | US | disclosed |
| WO-1991004250-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-04-04 | — | — | WO | disclosed |