Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.62 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595026 | 0.86 | ADRB1 (0.66) | ADRB1SMN1; SMN2GRIN2B | |
| SCHEMBL9670261 | 0.85 | ADRB1 (0.47) | ADRB1ACHEPOLBDRD2NPC1 | |
| SCHEMBL9595783 | 0.79 | ALDH1A1 (0.45) | ADRB1POLBNPC1RAB9AROCK2 | |
| Hydrochloric Acid SCHEMBL9594985 | 0.78 | ADRB1 (0.59) | ADRB1NPC1ARHPGDRAB9A | |
| SCHEMBL9596252 | 0.77 | ADRB1 (1.00) | ADRB1HPGD | |
| SCHEMBL8781020 | 0.74 | DRD4 (0.60) | ADRB1POLBDRD2 | |
| SCHEMBL25288 | 0.71 | SIGMAR1 (0.53) | POLB | |
| SCHEMBL9594552 | 0.71 | SIGMAR1 (0.50) | ACHEBACE1POLBDRD2GRIN2B | |
| SCHEMBL25154608 | 0.70 | DRD4 (0.46) | SMN1; SMN2GRIN2B | |
| SCHEMBL25154267 | 0.70 | DRD4 (0.46) | SMN1; SMN2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223623-A | 2-substituted-1(4)-aryl piperazines and the process for their preparation | SCHERING AG (DE) | 1993-06-29 | — | — | US | disclosed |
| EP-0491709-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-07-01 | — | — | EP | disclosed |
| US-5051422-A | 2-substituted-1(4)-aryl piperazines and the process for their preparation | SCHERING AG (DE) | 1991-09-24 | — | — | US | disclosed |
| WO-1991004250-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-04-04 | — | — | WO | disclosed |