Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.48 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387259 | 0.92 | OPRM1 (0.48) | OPRM1OPRK1HDAC8HDAC1HDAC2 | |
| SCHEMBL11055845 | 0.89 | OPRM1 (0.53) | OPRM1OPRK1HDAC8HDAC1HDAC2 | |
| SCHEMBL11051207 | 0.81 | HTR1A (0.46) | OPRM1OPRK1HDAC8HDAC1HDAC2 | |
| SCHEMBL9599601 | 0.77 | OPRM1 (0.51) | OPRM1OPRK1HDAC8HDAC1HDAC2 | |
| SCHEMBL20788100 | 0.73 | OPRM1 (1.00) | OPRM1OPRK1L3MBTL1 | |
| SCHEMBL28851671 | 0.72 | CYP2D6 (0.47) | OPRM1OPRK1HDAC8HDAC1HDAC2 | |
| Hexane SCHEMBL28019996 | 0.72 | EPHX2 (0.56) | L3MBTL1 | |
| SCHEMBL8560553 | 0.70 | OPRM1 (0.49) | OPRM1OPRK1HDAC8HDAC1HDAC2 | |
| SCHEMBL2358733 | 0.70 | MTNR1A (0.40) | OPRM1OPRK1HDAC8HDAC1HDAC2 | |
| SCHEMBL29159488 | 0.69 | OPRM1 (0.54) | OPRM1OPRK1HDAC8HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538248-A4 | — | — | 1994-08-03 | — | — | EP | claimed |
| EP-0538248-A1 | TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO [2,3-B]INDOLE | HOECHST MARION ROUSSEL, INC. (US) | 1993-04-28 | — | — | EP | claimed |