Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.74 |
| ▸ | DRD3 | P35462 | 8/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.74 |
| ▸ | HTR1A | P08908 | 7/20 | 0.64 |
| ▸ | DRD4 | P21917 | 7/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.64 |
| ▸ | HTR7 | P34969 | 6/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.64 |
| ▸ | HTR2C | P28335 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.61 |
| ▸ | DRD1 | P21728 | 3/20 | 0.61 |
| ▸ | DRD5 | P21918 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9603058 | 0.94 | DRD2 (0.79) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| SCHEMBL13532634 | 0.85 | DRD2 (1.00) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL9601414 | 0.82 | DRD2 (0.64) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL9603075 | 0.81 | SLC6A2 (0.64) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| SCHEMBL4752716 | 0.79 | DRD3 (0.57) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| SCHEMBL595744 | 0.79 | SLC6A2 (0.85) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| SCHEMBL9601301 | 0.79 | DRD2 (0.56) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| SCHEMBL5023694 | 0.78 | DRD2 (0.65) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| SCHEMBL10833537 | 0.78 | DRD3 (0.55) | DRD2DRD3SIGMAR1HTR1ADRD4 | |
| SCHEMBL13532638 | 0.77 | HTR1A (0.88) | DRD2DRD3SIGMAR1HTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308476-B1 | BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION | Kabi Pharmacia AB (SE) | 1993-02-03 | — | — | EP | disclosed |
| US-4937245-A | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | FEX TOMAS (SE) | 1990-06-26 | — | — | US | disclosed |