SCHEMBL9601301

SCHEMBL9601301

Cc1ccnc(N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 8/20 0.56
DRD3 P35462 8/20 0.56
SIGMAR1 Q99720 4/20 0.56
HTR2A P28223 4/20 0.49
SLC6A4 P31645 3/20 0.49
SLC6A3 Q01959 3/20 0.49
HRH1 P35367 3/20 0.49
CYP3A4 P08684 2/20 0.49
CYP2D6 P10635 2/20 0.49
CYP1A2 P05177 2/20 0.49
CYP2C9 P11712 2/20 0.49
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
KCNH2 Q12809 2/20 0.49
SLC6A2 P23975 2/20 0.49
ADORA3 P0DMS8 2/20 0.49
ADRA1A P35348 2/20 0.49
OPRD1 P41143 2/20 0.49
OPRK1 P41145 2/20 0.49
ADRA2C P18825 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9603058 0.81 DRD2 (0.79) DRD2DRD3SIGMAR1HTR2ASLC6A4
SCHEMBL9601362 0.79 DRD2 (0.74) DRD2DRD3SIGMAR1HTR2ASLC6A4
SCHEMBL10833537 0.79 DRD3 (0.55) DRD2DRD3SIGMAR1HTR2ASLC6A4
Hydrochloric Acid SCHEMBL9603075 0.77 SLC6A2 (0.64) DRD2DRD3SIGMAR1HTR2ASLC6A4
SCHEMBL9602967 0.76 SIGMAR1 (0.79) DRD2SIGMAR1CYP1A2CYP2C9KDM4E
SCHEMBL10363644 0.75 USP2 (0.56) DRD2DRD3SIGMAR1HTR2ASLC6A4
Hydrochloric Acid SCHEMBL9601661 0.75 SIGMAR1 (0.67) DRD2DRD3SIGMAR1HTR2ASLC6A4
SCHEMBL28876807 0.75 CYP3A4 (0.64) DRD2DRD3SIGMAR1HTR2ASLC6A4
Oxalic Acid SCHEMBL9602525 0.74 DRD3 (0.58) DRD2DRD3SIGMAR1HTR2ASLC6A4
SCHEMBL5023694 0.74 DRD2 (0.65) DRD2DRD3SIGMAR1HTR2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308476-B1 BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION Kabi Pharmacia AB (SE) 1993-02-03 EP disclosed