Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602776 | 0.82 | PKM (0.64) | PKMKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11773546 | 0.82 | PKM (0.61) | HDAC1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL1026665 | 0.75 | HDAC1 (0.57) | HDAC1KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL14640610 | 0.74 | RYR2 (0.65) | HDAC1PKMKMT2AMEN1HTT | |
| SCHEMBL5708819 | 0.74 | GAA (0.62) | PKMKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL7006375 | 0.72 | HDAC1 (0.57) | HDAC1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL9757210 | 0.72 | HDAC1 (0.54) | HDAC1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL382362 | 0.72 | HDAC1 (0.54) | HDAC1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL4715745 | 0.72 | PKM (0.52) | PKMKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL9757496 | 0.72 | HDAC1 (0.54) | HDAC1PKMKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227986-B1 | ISOINDOLINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-03-24 | — | — | EP | disclosed |
| US-4987235-A | Isoindoline derivatives and processes for their preparation | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| EP-0227986-A1 | Isoindoline derivatives and processes for their preparation | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1987-07-08 | — | — | EP | disclosed |