Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715745 | 0.88 | PKM (0.52) | PKMLMNAMEN1KMT2ARYR2 | |
| SCHEMBL11773546 | 0.87 | PKM (0.61) | PKMLMNAMEN1KMT2ARYR2 | |
| SCHEMBL14640610 | 0.85 | RYR2 (0.65) | PKMLMNAMEN1KMT2ARYR2 | |
| SCHEMBL9601466 | 0.82 | HDAC1 (0.51) | PKMLMNAMEN1KMT2ARYR2 | |
| SCHEMBL29108055 | 0.82 | PKM (0.68) | PKMLMNAMEN1KMT2ARYR2 | |
| SCHEMBL7496042 | 0.81 | RYR2 (0.49) | PKMLMNAMEN1KMT2ARYR2 | |
| SCHEMBL17137356 | 0.79 | ALDH1A1 (0.51) | PKMLMNAMEN1KMT2ARYR2 | |
| SCHEMBL5708819 | 0.78 | GAA (0.62) | PKMLMNAMEN1KMT2ACYP2C19 | |
| SCHEMBL5915342 | 0.77 | PDE4B (0.81) | PKMLMNAKMT2APDE4BPDE4D | |
| SCHEMBL16637857 | 0.77 | HDAC1 (0.49) | PKMLMNARYR2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227986-B1 | ISOINDOLINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-03-24 | — | — | EP | disclosed |
| US-4987235-A | Isoindoline derivatives and processes for their preparation | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| EP-0227986-A1 | Isoindoline derivatives and processes for their preparation | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1987-07-08 | — | — | EP | disclosed |