Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602826 | 0.99 | ATM (0.48) | ATMCYP2D6CYP2C19CACNA1GADORA2A | |
| SCHEMBL9602470 | 0.93 | KDM4E (0.51) | CACNA1GABCB1MEN1KMT2AKDM4E | |
| SCHEMBL9602054 | 0.92 | SMN1; SMN2 (0.48) | CACNA1GADORA2AABCB1MEN1KMT2A | |
| SCHEMBL9602957 | 0.85 | PTGS1 (0.42) | CYP2D6CYP2C19MEN1KMT2AKDM4E | |
| SCHEMBL9602165 | 0.83 | HRH3 (0.41) | KMT2ADRD2 | |
| SCHEMBL9601550 | 0.83 | HRH3 (0.40) | KMT2ADRD2 | |
| SCHEMBL9603116 | 0.83 | CYP2D6 (0.41) | CYP2D6MEN1KMT2ATSHR | |
| SCHEMBL9867239 | 0.82 | HRH3 (0.39) | DRD2 | |
| SCHEMBL9602428 | 0.81 | HRH3 (0.41) | KMT2ADRD2 | |
| SCHEMBL9602093 | 0.80 | HRH3 (0.39) | MEN1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |