Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ALB | P02768 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ADA | P00813 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Didanosine SCHEMBL3364 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL1769151 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL12150307 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| Didanosine SCHEMBL29387997 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| SCHEMBL887896 | 0.82 | ALDH1A1 (0.51) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| SCHEMBL23254277 | 0.81 | ALDH1A1 (0.60) | ALDH1A1LMNAALBMAPK1CYP1A2 | |
| SCHEMBL9197787 | 0.81 | ADA (0.65) | ALDH1A1LMNAALBMAPK1ADA | |
| SCHEMBL1374909 | 0.81 | ADA (0.65) | ALDH1A1LMNAALBMAPK1ADA | |
| SCHEMBL8094890 | 0.81 | ADA (0.65) | ALDH1A1LMNAALBMAPK1ADA | |
| SCHEMBL20419221 | 0.81 | ADA (0.65) | ALDH1A1LMNAALBMAPK1ADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355135-B1 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1993-08-04 | — | — | EP | disclosed |
| US-4997926-A | Viricides | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0355135-A4 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES. | SCRIPPS CLINIC RES (US) | 1990-04-09 | — | — | EP | disclosed |
| EP-0355135-A1 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1990-02-28 | — | — | EP | disclosed |
| WO-1989004662-A1 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1989-06-01 | — | — | WO | disclosed |