Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452029 | 0.69 | MAOA (0.50) | HRH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7915833 | 0.69 | MAOA (0.50) | HRH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9601979 | 0.68 | HRH1 (0.38) | HRH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20069016 | 0.66 | SLC6A4 (0.44) | HRH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL28270390 | 0.65 | HRH1 (0.44) | HRH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31617176 | 0.65 | HRH1 (0.38) | HRH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3984810 | 0.62 | L3MBTL1 (0.40) | HRH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL21940865 | 0.61 | HRH4 (0.41) | HRH1LMNAHRH3HRH4 | |
| SCHEMBL29375684 | 0.59 | — | — | |
| SCHEMBL10672099 | 0.59 | HRH1 (0.67) | HRH1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206415-B1 | (4-PIPERIDINYLMETHYL AND -HETERO)PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-01-27 | — | — | EP | disclosed |