Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692023 | 0.81 | SMN1; SMN2 (0.37) | ALDH1A1KDM4EKMT2AHPGDLMNA | |
| SCHEMBL10410572 | 0.81 | IKBKB (0.40) | ALDH1A1KDM4EKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9602976 | 0.78 | KMT2A (0.45) | ALDH1A1KDM4EKMT2AHPGDLMNA | |
| SCHEMBL9154888 | 0.76 | KDM4E (0.48) | ALDH1A1KDM4EKMT2AHPGDLMNA | |
| SCHEMBL14300893 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1KDM4EKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9602155 | 0.75 | KDM4E (0.37) | ALDH1A1KDM4EKMT2AHPGDLMNA | |
| SCHEMBL10683157 | 0.75 | SMN1; SMN2 (0.42) | ALDH1A1KDM4EKMT2AHPGDLMNA | |
| SCHEMBL3656469 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL7213607 | 0.73 | POLB (0.49) | ALDH1A1KDM4EKMT2AHPGDLMNA | |
| Water SCHEMBL10410161 | 0.72 | ALDH1A1 (0.59) | ALDH1A1KDM4EKMT2AHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184027-B1 | PREPARATION OF SUBSTITUTED AND UNSUBSTITUTED 2-CARBAMOYL NICOTINIC AND 3-QUINOLINECARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1990-02-07 | — | — | EP | claimed |
| EP-0144595-B1 | PREPARATION OF 2-CARBAMOYL NICOTINIC AND 3-QUINOLINE CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1989-01-18 | — | — | EP | claimed |
| US-4782157-A | FROM CORRESPONDING ANHYDRIDES | AMERICAN CYANAMID CO. (US) | 1988-11-01 | — | — | US | claimed |
| EP-0184027-A2 | Preparation of substituted and unsubstituted 2-carbamoyl nicotinic and 3-quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1986-06-11 | — | — | EP | claimed |
| US-4562257-A | HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1985-12-31 | — | — | US | claimed |
| EP-0144595-A1 | Preparation of 2-carbamoyl nicotinic and 3-quinoline carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1985-06-19 | — | — | EP | claimed |
| EP-0205879-B1 | PROCESS FOR THE PREPARATION OF HERBICIDAL 2-(4,4-DISUBSTITUTED 5-OXO-2-IMIDAZOLIN-2-YL)BENZOIC, NICOTINIC AND QUINOLINE-3-CARBOXYLIC ACIDS, ESTERS AND SALTS | AMERICAN CYANAMID COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0184027-B1 | PREPARATION OF SUBSTITUTED AND UNSUBSTITUTED 2-CARBAMOYL NICOTINIC AND 3-QUINOLINECARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1990-02-07 | — | — | EP | disclosed |
| EP-0095105-B1 | PROCESS FOR THE PREPARATION OF 2-(5,5-DISUBSTITUTED-4-OXO-2-IMIDAZOLIN-2-YL)-NICOTINIC ACIDS, QUINOLINE-3-CARBOXYLIC ACIDS, AND BENZOIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1988-01-27 | — | — | EP | disclosed |
| US-4719303-A | Preparation of substituted and unsubstituted 2-[(1-carbamoyl-1,2-dimethylpropyl)-carbamoyl]-3-quinolinecarboxylic, nicotinic and benzoic acids | AMERICAN CYANAMID COMPANY (US) | 1988-01-12 | — | — | US | disclosed |
| US-4709036-A | Process for the preparation of herbicidal 2-(4,4-disubstituted-5-oxo-2-imidazolin-2-yl)benzoic, nicotinic and quinoline-3-carboxylic acids, esters and salts | AMERICAN CYANAMID COMPANY (US) | 1987-11-24 | — | — | US | disclosed |
| US-4658030-A | BASE-CATALYZED CYCLIZATION OF SUBSTITUTED 2-CARBAMOYL NICOTINIC ACIDS, 3-QUINOLINECARBOXYLIC OR BENZOIC ACIDS, HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0205879-A2 | Process for the preparation of herbicidal 2-(4,4-disubstituted 5-oxo-2-imidazolin-2-yl)benzoic, nicotinic and quinoline-3-carboxylic acids, esters and salts | AMERICAN CYANAMID COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0184027-A2 | Preparation of substituted and unsubstituted 2-carbamoyl nicotinic and 3-quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1986-06-11 | — | — | EP | disclosed |
| EP-0142718-A1 | Preparation of substituted and unsubstituted 2-((1-carbamoyl-1,2-dimethylpropyl)-carbamoyl)-3-quinolinecarboxylic, nicotinic and benzoic acids | AMERICAN CYANAMID COMPANY (US) | 1985-05-29 | — | — | EP | disclosed |
| US-4518780-A | BASE CATALYZED CYCLIZATION OF 2-CARBAMOYLNICOTINIC ACID, 3-QUIOLINECARBOXYLIC OR BENZOIL ACIDS | AMERICAN CYANAMID COMPANY (US) | 1985-05-21 | — | — | US | disclosed |
| WO-1983004253-A1 | PROCESS FOR THE PREPARATION OF 2-(5,5-DISUBSTITUTED-4-OXO-2-IMIDAZOLIN-2-YL)-NICOTINIC, QUINOLINE-3-CARBOXYLIC AND BENZOIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1983-12-08 | — | — | WO | disclosed |
| EP-0095105-A2 | Process for the preparation of 2-(5,5-disubstituted-4-oxo-2-imidazolin-2-yl)-nicotinic acids, quinoline-3-carboxylic acids, and benzoic acids | AMERICAN CYANAMID COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |