Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.61 |
| ▸ | APP | P05067 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 4/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.49 |
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631114 | 0.87 | HSD17B1 (0.77) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL28073052 | 0.85 | APP (0.68) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL29766071 | 0.85 | APP (0.71) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL163523 | 0.85 | APP (0.71) | HSD17B1HSD17B2APPCA1CA2 | |
| Bromide SCHEMBL31564934 | 0.83 | APP (0.69) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL32677328 | 0.82 | APP (0.81) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL27159530 | 0.82 | APP (0.81) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL30340807 | 0.81 | HSD17B1 (0.75) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL5768436 | 0.81 | APP (0.72) | HSD17B1HSD17B2APPCA1CA2 | |
| SCHEMBL5682837 | 0.80 | ESR1 (0.53) | HSD17B1HSD17B2APPESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483475-B | Method for preparing benzothiophene compound by silver oxide catalysis method | 绍兴文理学院 | 2020-11-27 | — | — | CN | disclosed |
| CN-110483475-A | A kind of method that silver oxide catalysis method prepares benzothiophenes | UNIV SHAOXING | 2019-11-22 | — | — | CN | disclosed |
| EP-0279263-B1 | INDOLE, BENZOFURAN, BENZOTHIOPHENE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-08-04 | — | — | EP | disclosed |
| US-4873259-A | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0279263-A2 | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |