Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.52 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9600966 | 0.84 | DPP4 (0.55) | DPP4DPP8DPP9MAOB | |
| SCHEMBL9600526 | 0.83 | DPP4 (0.47) | DPP4DPP8DPP9CYP3A4AHR | |
| SCHEMBL9601003 | 0.82 | DPP4 (0.49) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL9600968 | 0.79 | DPP4 (0.49) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL9601457 | 0.78 | CSNK2A1 (0.51) | DPP4CYP3A4 | |
| SCHEMBL9602733 | 0.76 | DPP4 (0.36) | DPP4DPP8DPP9CYP3A4AHR | |
| SCHEMBL29473775 | 0.73 | CA1 (0.51) | MAOBABL1ABCB1BCRCA1 | |
| SCHEMBL9600455 | 0.72 | DPP4 (0.52) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL15129491 | 0.71 | TAAR1 (0.42) | DPP4 | |
| SCHEMBL7690453 | 0.70 | CA1 (0.49) | DPP4CYP3A4MAOBABL1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318181-B1 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5169976-A | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| WO-1989004821-A1 | N-(BIPHENYLMETHYL)-3-HYDROXYGLUTARAMIC ACID AND DERIVATIVES AS HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1989-06-01 | — | — | WO | disclosed |
| EP-0318181-A2 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1989-05-31 | — | — | EP | disclosed |