Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.47 |
| ▸ | AHR | P35869 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9601003 | 0.87 | DPP4 (0.49) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL9600968 | 0.87 | DPP4 (0.49) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL9601457 | 0.87 | CSNK2A1 (0.51) | DPP4CYP3A4 | |
| SCHEMBL9602733 | 0.84 | DPP4 (0.36) | DPP4AHRDPP8DPP9CYP3A4 | |
| SCHEMBL9602419 | 0.83 | DPP4 (0.52) | DPP4AHRDPP8DPP9CYP3A4 | |
| SCHEMBL9600455 | 0.76 | DPP4 (0.52) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL9601814 | 0.76 | DPP4 (0.52) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL2090996 | 0.76 | ALDH1A1 (0.45) | DPP4AHRDPP8CYP3A4 | |
| SCHEMBL9602126 | 0.74 | PNMT (0.39) | DPP4DPP8DPP9 | |
| SCHEMBL4247286 | 0.74 | AHR (0.47) | AHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318181-B1 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5169976-A | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0318181-A2 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1989-05-31 | — | — | EP | disclosed |