Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9600526 | 0.84 | DPP4 (0.47) | DPP4CYP3A4DPP8DPP9AHR | |
| SCHEMBL9601457 | 0.82 | CSNK2A1 (0.51) | DPP4CYP3A4CSNK2A1 | |
| SCHEMBL9601003 | 0.80 | DPP4 (0.49) | DPP4CYP3A4DPP8DPP9 | |
| SCHEMBL9600968 | 0.80 | DPP4 (0.49) | DPP4CYP3A4DPP8DPP9TP53 | |
| SCHEMBL2090996 | 0.79 | ALDH1A1 (0.45) | DPP4CYP3A4DPP8ALDH1A1TSHR | |
| SCHEMBL9600455 | 0.76 | DPP4 (0.52) | DPP4CYP3A4DPP8DPP9ALDH1A1 | |
| SCHEMBL9601814 | 0.76 | DPP4 (0.52) | DPP4CYP3A4DPP8DPP9TAAR1 | |
| SCHEMBL9602419 | 0.76 | DPP4 (0.52) | DPP4CYP3A4DPP8DPP9AHR | |
| SCHEMBL9602126 | 0.73 | PNMT (0.39) | DPP4DPP8DPP9CSNK2A1TAAR1 | |
| SCHEMBL9600966 | 0.72 | DPP4 (0.55) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318181-B1 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5169976-A | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0318181-A2 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1989-05-31 | — | — | EP | disclosed |