Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.51 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602419 | 0.84 | DPP4 (0.52) | DPP4DPP8DPP9MAOB | |
| SCHEMBL9600455 | 0.81 | DPP4 (0.52) | DPP4DPP8DPP9CNR1 | |
| SCHEMBL9602126 | 0.78 | PNMT (0.39) | DPP4DPP8DPP9 | |
| SCHEMBL9601457 | 0.78 | CSNK2A1 (0.51) | DPP4 | |
| SCHEMBL9601814 | 0.78 | DPP4 (0.52) | DPP4DPP8DPP9 | |
| SCHEMBL7566898 | 0.73 | MTNR1A (0.42) | DPP4MGAT2MAOBPRKAB2PRKAG1 | |
| SCHEMBL9600526 | 0.73 | DPP4 (0.47) | DPP4DPP8DPP9 | |
| SCHEMBL9602733 | 0.72 | DPP4 (0.36) | DPP4DPP8DPP9 | |
| SCHEMBL9601003 | 0.72 | DPP4 (0.49) | DPP4DPP8DPP9 | |
| SCHEMBL7579760 | 0.72 | CASR (0.58) | MAOBTDO2PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318181-B1 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5169976-A | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| WO-1989004821-A1 | N-(BIPHENYLMETHYL)-3-HYDROXYGLUTARAMIC ACID AND DERIVATIVES AS HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1989-06-01 | — | — | WO | disclosed |
| EP-0318181-A2 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1989-05-31 | — | — | EP | disclosed |