Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877627 | 0.96 | MEN1 (0.54) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL7673493 | 0.90 | MEN1 (0.54) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL9678351 | 0.82 | MEN1 (0.51) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| Phosphoric Acid SCHEMBL8773247 | 0.82 | POLB (0.50) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL16131299 | 0.80 | MEN1 (0.60) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL770722 | 0.80 | CYP1A2 (0.70) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL5709546 | 0.80 | MEN1 (0.56) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL11785649 | 0.77 | MEN1 (0.54) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL27724708 | 0.77 | CYP2D6 (0.51) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL6273072 | 0.77 | MEN1 (0.47) | MEN1KMT2AKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250676-B1 | NON-ENZYMATIC IMMUNOHISTOCHEMICAL STAINING SYSTEM AND REAGENTS | Immunomedics, Inc. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-4792521-A | Non-enzymatic immunohistochemical staining system and reagents | IMMUNOMEDICS, INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0250676-A2 | Non-enzymatic immunohistochemical staining system and reagents | Immunomedics, Inc. (US) | 1988-01-07 | — | — | EP | disclosed |