Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 4/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10445204 | 0.93 | HRH3 (0.42) | HRH3ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL9866414 | 0.90 | HRH3 (0.38) | HRH3ALDH1A1MAPTKDM4ECDK4 | |
| SCHEMBL9602742 | 0.88 | HRH3 (0.45) | HRH3ALDH1A1LMNAHPGDALOX12 | |
| SCHEMBL9602846 | 0.87 | MCHR1 (0.41) | HRH3ALDH1A1LMNAHPGDALOX12 | |
| SCHEMBL9866371 | 0.87 | HRH3 (0.41) | HRH3ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL9866408 | 0.84 | MCHR1 (0.38) | HRH3 | |
| SCHEMBL9867236 | 0.79 | MCHR1 (0.44) | HRH3ALDH1A1LMNAHPGDALOX12 | |
| SCHEMBL10368024 | 0.79 | ALDH1A1 (0.50) | ALDH1A1LMNAHPGDALOX12MAPT | |
| SCHEMBL9602093 | 0.78 | HRH3 (0.39) | HRH3ALDH1A1KMT2A | |
| SCHEMBL9865164 | 0.78 | MAOB (0.37) | HRH3ALDH1A1LMNAHPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |